PAT for Continuous Chromatography Integrated into Continuous Manufacturing of Biologics towards Autonomous Operation
نویسندگان
چکیده
منابع مشابه
Integrated operation of continuous chromatography and biotransformations for the generic high yield production of fine chemicals.
The rapid progress in biocatalysis in the identification and development of enzymes over the last decade has enormously enlarged the chemical reaction space that can be addressed not only in research applications, but also on industrial scale. This enables us to consider even those groups of reactions that are very promising from a synthetic point of view, but suffer from drawbacks on process l...
متن کاملTowards Integrated Continuous-Flow Chemical Reactors
A device for rapid mixing of two solutions is presented. As the main mechanism for mixing is diffusional mass transport, the ̄ow has to be split into several laminae which are narrower than the capillary width. Complete mixing is achieved within a few seconds in a ̄ow-through device with a channel system that is 600mm wide at its narrowest spot.
متن کاملEvaluation of the Financial Impact of Continuous Chromatography in the Production of Biologics
The primary goal of this internship is to explore the financial impact of changing one or more of the downstream chromatography steps involved in the purification of a complex biologic molecule from a batch process to a continuous one. This is particularly relevant, as biologics represent the fastest growing segment of the human therapeutics market, and, consequently, have become a major compon...
متن کاملNew Continuous Chromatography Options
Why continuous chromagraphic processes should be explored One of the most powerful and increasingly more relied upon purification methods used in pharmaceuticals and biotechnology is chromatography. This application has also acquired added significance as regulatory bodies have required higher and higher purity and reproducibility in the new products being developed. This is especially true in ...
متن کاملLearning Integrated Symbolic and Continuous Action Models for Continuous Domains
Long-living autonomous agents must be able to learn to perform competently in novel environments. One important aspect of competence is the ability to plan, which entails the ability to learn models of the agent’s own actions and their effects on the environment. In this paper we describe an approach to learn action models of environments with continuous-valued spatial states and realistic phys...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Processes
سال: 2021
ISSN: 2227-9717
DOI: 10.3390/pr9030472